Neurodegeneration and Brain Health

Key Indications

Spermidine can trigger the activation of autophagy which may remove harmful toxic proteins causing diseases such as Parkinson's, Alzheimers, or ALS. This effect was discovered in mice as well as human studies.

Human Studies

  • Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. Learn More.

  • The effect of spermidine on memory performance with older adults at risk for dementia: A randomized controlled trial. Learn More.

Animal Studies

  • Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43. Learn More.

  • Influence of microRNA deregulation on chaperone-mediated autophagy and a-synuclein pathology in Parkinson's disease. Learn More.

  • Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage.

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