Key Indications
Polyamines such as spermidine may carry the potential to reduce white adipose tissue and to stimulate the oxidation of fat in the body. Spermidine-induced autophagy may protect wild type mice from the harmful effects of a high-fat diet.
Animal Studies
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Learn More.
Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. Learn More.
Exogenous administration of spermidine improves glucose utilization and decreases bodyweight in mice. Learn More.
Autophagy Counteracts Weight Gain, Lipotoxicity and Pancreatic B-Cell Death upon Hypercaloric pro-Diabetic Regimens. Learn More.