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Diabetes & Obesity

Key Indications

Polyamines such as spermidine may carry the potential to reduce white adipose tissue and to stimulate the oxidation of fat in the body. Spermidine-induced autophagy may protect wild type mice from the harmful effects of a high-fat diet.

Animal Studies

  • Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Learn More.

  • Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. Learn More.

  • Exogenous administration of spermidine improves glucose utilization and decreases bodyweight in mice. Learn More.

  • Autophagy Counteracts Weight Gain, Lipotoxicity and Pancreatic B-Cell Death upon Hypercaloric pro-Diabetic Regimens. Learn More.


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