Key Indications
Spermidine may have a preventative effect on age-related cardiovascular diseases. Spermidine may improve cellular respiration by increasing the mitochondrial content of heart cells. Myocardial muscle cells, the so-called cardiomyocytes, which are responsible for the contraction of the heart, take up spermidine via a specific cellular transporter, potentially triggering autophagy. Increased NO availability in these cells may lead to reduced systemic inflammation.
Human Studies
Food Polyamine and Cardiovascular Disease - An Epidemiological Study. Learn More.
Animal Studies
Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy. Learn More.
Cardioprotection and lifespan extension by the natural polyamine spermidine. Learn More.
Beneficial effects of spermidine on cardiovascular health and longevity suggest a cell type-specific import of polyamines by cardiomyocytes. Learn More.
Polyamines and microbiota in bicuspid and tricuspid aortic valve aortopathy.