Cardiovascular Health

Key Indications

Spermidine may have a preventative effect on age-related cardiovascular diseases. Spermidine may improve cellular respiration by increasing the mitochondrial content of heart cells. Myocardial muscle cells, the so-called cardiomyocytes, which are responsible for the contraction of the heart, take up spermidine via a specific cellular transporter, potentially triggering autophagy. Increased NO availability in these cells may lead to reduced systemic inflammation.

Human Studies

  • Food Polyamine and Cardiovascular Disease - An Epidemiological Study. Learn More.

Animal Studies

  • Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy. Learn More.

  • Cardioprotection and lifespan extension by the natural polyamine spermidine. Learn More.

  • Beneficial effects of spermidine on cardiovascular health and longevity suggest a cell type-specific import of polyamines by cardiomyocytes. Learn More.

  • Polyamines and microbiota in bicuspid and tricuspid aortic valve aortopathy.

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