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Liver Health

Key Indications

Spermidine may increase liver protection by strengthening the NRF2 signal transduction via MAP1S-translated non-canonical mechanism. Spermidine may extend the lifespan and help prevent liver fibrosis as well as hepatocellular carcinoma by activating MAP1S-translated autophagy.

Animal Studies

  • Spermidine Confers Liver Protection by Enhancing NRF2 Signaling Through a MAP1S-Mediated Noncanonical Mechanism. Learn More.

  • Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy.


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